Capecitabine and Temozolomide in Advanced Lung Neuroendocrine Neoplasms
نویسندگان
چکیده
منابع مشابه
Temozolomide in Advanced Neuroendocrine Neoplasms: Pharmacological and Clinical Aspects.
Alkylating agents, such as streptozocin and dacarbazine, have been reported as active in neuroendocrine neoplasms (NENs). Temozolomide (TMZ) is an oral, potentially less toxic derivative of dacarbazine, which has shown activity both as a single agent and in combination with other drugs. Nevertheless, its role in NENs has not been well defined. Several retrospective and prospective phase I-II st...
متن کاملNeoadjuvant Chemotherapy with Capecitabine and Temozolomide for Unresectable Pancreatic Neuroendocrine Tumor
Pancreatic neuroendocrine tumors (PNETs) are relatively rare tumors that arise in the endocrine cells of the pancreas. Historically, somatostatin analogues have been used in this disease primarily for symptom control and, to a limited extent, disease stability. More recently, sunitinib and everolimus have been approved for advanced stage PNETs based on a survival benefit. However, both agents h...
متن کاملProfile of capecitabine/temozolomide combination in the treatment of well-differentiated neuroendocrine tumors
Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and therapy options are limited. Octreotide analogs and tyrosine kinase inhibitors are ...
متن کاملTreatment of metastatic neuroendocrine tumors of the thymus with capecitabine and temozolomide: a case series.
BACKGROUND Metastatic neuroendocrine tumors of the thymus are exceedingly rare with an annual incidence of approximately 0.2 per 1,000,000. They are highly resistant to therapy and there have been no reports of an objective radiographic response to treatment. MATERIALS AND METHODS The authors retrospectively evaluated 3 patients with progressive, metastatic neuroendocrine tumors of the thymus...
متن کاملCD200 Expression in Neuroendocrine Neoplasms
Objectives CD200 expression has been well studied in hematopoietic malignancies; however, CD200 expression has not been well-characterized in neuroendocrine neoplasms. We examined CD200 expression in 391 neuroendocrine neoplasms from various anatomic sites. Methods Tissue blocks containing pulmonary small cell carcinoma, pulmonary carcinoid, large cell neuroendocrine carcinoma, pancreatic neu...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 2019
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2019-0361